http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134599/
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake
So for those of you who don't know me, I'm a big of transhumanism. I stumbled upon this just recently and thought you might like to discuss it / read it for your own private pleasure. The whole idea around this is gene therapy (manipulate our own genes), and RNA Interference (knock out gene expression - (process by which information from a gene is used in the synthesis of a functional gene product.)
Essentially what scientists have discovered is a way to decrease body weight, without any change in food intake (eat whatever you want). This is applicable only to mice at the moment, but the science behind this is badass, and hope we can extrapolate this to the human population (imagine the field day companies would have).